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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

L-Carnitine is a naturally occurring amino acid that plays a vital role in energy metabolism

Sulforaphane, a naturally occurring small molecule, activates the Nrf2-ARE pathway, upregulates antioxidant enzymes such as SOD and CAT, reduces ROS accumulation, and inhibits apoptosis

however, contemporary insights highlight a significant male contribution